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KMID : 0377519950200030191
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Chung-Ang Journal of Medicine
1995 Volume.20 No. 3 p.191 ~ p.214
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The Role of Age and Body Mass Index in Explaining the Effect of Risk Factors on copper, Zinc, Ceruloplasmin and Lipids
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Lee Young-Seob
Choi Byung-Sun
Park Jung-Duck
Chang Im-Won
Hong Yeon-Pyo
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Abstract
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To investigate the role of age and body mass index on serum level of copper, zinc, ceruloplasmin and lipids according to risk factors(smoking, alcohol intake, and physical activity), this study was performed in a cross-sectional study in 125 healthy men aged 20 to 40 years who had no symptomatic liver, heart, gastrointestinal, and other chronic diseases. At men’s entry into the study, blood samples were drawn from each subjects and immediately centrifuged for analysis of serum level of copper, zinc, copper zinc ratio, ceruloplasmin, and total cholesterol, triglyceride, low density lipoprotein cholesterol, and high density lipoprotein cholesterol as dependent variables, and each men completed a questionnaire that provided information on smoking history, daily smoking amount, pack years of smoking, history, duration and amount of alcohol intake, total energy expenditure, and frequency of moderate physical activity as independent variables. In general linear models adjusting for age and body mass index in most of all dependent variables did not show statistically differences, and there were just statistically differences in serum copper in smoking history, low density lipoprotein cholesterol in daily smoking amount, zinc in pack years of smoking, and high density lipoprotein cholesterol in history and duration of alcohol intake. These data indicate that age and body mass index may play a role as important confounding factors.
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KEYWORD
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serum, copper, zinc, ceruloplasmin, lipids, age, BMI, risk factor
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